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Undergraduate student and postdoc positions available
The focus of my research is the host pathogen interaction in infectious disease. First I am interested in how pathogens exploit cellular function in their life cycles. Secondly, I wish to study how these mechanisms of host cell exploitation are regulated. These studies are important not only for the better understanding of the biology of infectious disease and for developing new therapeutic strategies against them, but also for the better understanding of host cell biology, using infectious agents as an evolutionarily well-adapted tool in cell biology.
We investigate the interactions between Francisella tularensis subspecies novicida with host cells. More specificially we investigate the role of a genetic element in Francisella (the Francisella pathogenicity island) in pathogenesis.
In addition we are interested in other zoonotic pathogens and their distribution in the Alaska Ecosystem. This work is done oin close collaboration with the laboratory of Dr. Todd M. O'Hara here at UAF.
1993 - 1999 Veterinary degree, School of Vet Med Hannover (Germany)
1999 - 2003 PhD, Cornell University (with Colin R. Parrish)
2003 - 2006 Post graduate training, Yale School of Medicine (with Jorge E. Galán)
Pathel J. Hueffer K., Lam T. T., Galán J. E.: Diversification of a Salmonella effector protein function by ubiquitin-dependent differential localization. Accepted in CELL
Read A. Vogl S., Hueffer K., Gallagher L , and G. M. Happ. Francisella genes required for replication in mosquito cells. Journal of Medical Entomology 45 (2008) 1108-1116
Hueffer, K., and J. E. Galán.. Salmonella-induced macrophage death: multiple mechanisms, different outcomes. Cellular Microbiology 6 (2004) 1019-25.
Hernandez, L., Hueffer, K., Wenk, M., Galán, J. E.: Salmonella modulates vesicular trafficking by altering phosphoinositide metabolism. Science 304 (2004) 1805-1807.
Hueffer, K., Palermo, L., Parrish, C.: Parvovirus infection of cells using variants of the feline transferrin receptor altering - clathrin-mediated endocytosis, membrane domain localization and capsid binding domains. Journal of Virology 78 (2004) 5601–5611.
Hueffer, K., Truyen, U., Parrish, C. R.: Evolution und Wirtswechsel des Caninen Parvovirus: Molekulare Grundlagen der Entstehung eines neuen Virus
Berliner Muenchner Tieraerztliche Wochenschrift 117 (2004),130 - 135
Govindasamy, L., Hueffer, K., Parrish, C. R., Agbandje-McKenna, M.: Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants. Journal of Virology 77 (2003) 12211-12221.
Hueffer, K, Govindasamy, L., Agbandje-McKenna, M., Parrish, C. R.: Combinations of two capsid regions controlling canine host range determine canine transferrin receptor binding by canine and feline parvoviruses. Journal of Virology 77 (2003) 10099-10105.
Hueffer, K., Parrish C. R.: Parvovirus host range, cell tropism and evolution. Current Opinion in Microbiology 6 (2003) 392-398.
Palermo, L., Hueffer, K., Parrish, C. R.: Residues in the apical domain of the feline and canine transferrin receptors control host-specific binding and cell infection of canine and feline parvoviruses. Journal of Virology 77 (2003) 8915-8923.
Hueffer, K., Parker, J., Weichert, W., Geisel, R., Sgro, J., Parrish, C. R.: The natural host range shift and subsequent evolution of canine parvovirus resulted from virus-specific binding to the canine transferrin receptor. Journal of Virology 77 (2003) 1718-1726
Chen, C., Burton-Wurster, N., Bordon, C., Hueffer, K., Bloom, S., Lust, G.: Chondrocyte necrosis and apoptosis in impact damaged articular cartilage; Journal of Orthopaedical Research 19 (2001) 703-711
Book chapters:
Parrish, C. R., Hueffer, K.: Parvovirus host range, cell tropism and evolution – studies of canine and feline parvoviruses, minute virus of mice, porcine parvovirus, and Aleutian mink disease virus. Kerr, J.R., Cotmore, S.F., Bloom, M.E., Linden, R.M., and Parrish, C.R. eds. “Parvoviruses.” Edward Arnold Limited. London, UK. In press (November 2005) 343-351.
Presentations:
Hueffer, K., Palermo, L., Parrish, C. R.: Cell Infection Using the Transferrin Receptor Parvovirus Capsids Require a Specific Lipid environment and capsid interactions with the receptor ectodomain, but not clathrin mediated uptake. (Poster, American Society for Cell Biology 43st Annual Meeting, San Francisco, USA, 12/13-17 2003).
Govindasamy, L., Hueffer, K., Parrish, C. R., Agbanje McKenna, M.: Structural Studies of Canine Parvovirus Capsid Mutants Controlling Host Range and Receptor Binding. (Seminar, American Society for Virology, 22st Annual Meeting, Davis, USA, 7/20-24/2003).
Hueffer, K., Palermo, L., Parrish, C. R.: Using Mutant Transferrin Receptor to Define Pathways of Canine Parvovirus Cell Infection. (Seminar, American Society for Virology, 22st Annual Meeting, Davis, USA, 7/20-24/2003).
Hueffer, K., Parrish, C. R.: The Special Role of the Transferrin Receptor in the Entry and Infection of cells. (Poster, American Society for Cell Biology 41st Annual Meeting, Washington DC, USA, 12/8-12/2002).
Hueffer, K., Parrish, C. R.: The specific roles of the transferrin receptor in canine parvovirus cell infection. (Seminar, IX Parvovirus Workshop, Bologna Italy, 8/28-31/2002).
Parrish, C. R., Hueffer, K., Palermo, L.: Host range and Evolutionary Variation of feline and canine parvovirus is determined by specific binding and infection by transferrin receptor. (Seminar, IX Parvovirus Workshop, Bologna Italy, 8/28-31/2002).
Hueffer, K., Parker, J., Weichert, W., Geisel R., Sgro, J., Parrish, C. R.: Host range of canine parvovirus are controlled by specific binding to the canine transferrin receptor. (Seminar, American Society for Virology, 21st Annual Meeting, Lexinton, KY, USA, 7/20-24/2002).
Parrish, C. R., Hueffer, K., Parker, J., Weichert, W.: Binding of canine and feline parvoviruses to transferrinreceptors, and the role of the receptors in control of host range. (Seminar, American Society for Virology, 20th Annual Meeting, Madison, WI, USA, 7/21-25/2001).
Hueffer, K., Agbandje-McKenna, M., Parrish, C. R.: Host range and Antigenicity of Canine Parvovirus Mutants. (Seminar, American Society for Virology, 20th Annual Meeting, Madison, USA, 7/21-25/2001).Hueffer, K, Agbandje-McKenna M., Parrish C. R.: Host range and Antigenicity of Canine Parvovirus Mutants. (Seminar, Third International Virus Assembly Symposium, Seeon, Germany 4/1-5/2001)
Hueffer, K., Parrish, C. R.: Host Range and Antigenicity of Canine Parvovirus Mutants. (Poster, VIIIth Parvovirus Workshop, Mont Tremblant, Canada 6/28-7/2/2000
Teaching
Fall 2006 Concepts of infectious diseases (Biol 493 / 693) University of ALaska Fairbanks
Fall 2006 Guest lecturer dental hyginist course (Emerging infectious disease lecture)
Tanana Valley Community college
Spring 2007 Microbiology (Biol 342)
1996 H. Wilhelm Schaumann Stiftung award (Preis für beste Studienleistungen)
1999 – 2001 Graduate Research Assistantship (College of Vet. Med., Cornell)
2001 – 2002 Stockler Fellowship (Graduate School, Cornell University)
2003 Award for Scholarship in Basic Science, Alpha Chapter of Phi Zeta
2004 – 2006 Damon Runyon Cancer Research Foundation Fellow
1997- 1998 Student representative in the central study commission at the Veterinary School Hannover.
1997-1998 Chairman of student parliament at the Veterinary School Hannover
Fall 1997/98 Chairman of the Election Commission for student parliament, Veterinary School Hannover
Summer 1998 Student representative in the Leadership Program for Veterinary Students Cornell University
2001 - 2002 Representative of Biological Sciences in the Graduate and Professional Students Assembly
2001 - 2002 Graduate Student representative in the University Assembly
2001 - 2002 Member of the Executive Committee to the University Assembly
2001 - 2003 Member of Graduate and Professional Student Assembly Finance Committee (Chair 01 – 02)
2001 - 2003 Member of the Campus Planning Committee Cornell University
Students
Alison N. Triebenbach
Rebekah Hare-Sanford
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